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KMID : 1094720090140010112
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Biotechnology and Bioprocess Engineering
2009 Volume.14 No. 1 p.112 ~ p.117
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Enrichment of Bakuchiol in Supercritical Carbon Dioxide Extracts of Chiba Seed (Psoralea corylifolia L.) Using Molecular Distillation - Response Surface Methodology
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Manohar B.
Udaya Sankar K.
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Abstract
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Chiba seed (Psoralea corylifolia L.) oil, which contains bioactive components such as bakuchiol, psoralen, and isosporalen, is recognized for its high medicinal value and is widely used in Chinese and Indian Ayurvedic medicinal systems. Several earlier studies have proved the antibacterial and antioxidant properties of the key components in the seed oil. In view of the importance of the bioactive components in the global market, this study was carried out to separate the key components by supercritical carbon dioxide extraction and further enrichment by the molecular distillation technique. The effects of the process variables such as pressure (400~2,000 μm), temperature (140~200℃), and wiper speed (120~200 rpm) were studied based on response surface methodology. The predicted model was maximized for the bakuchiol content in the distillate. And a predicted maximum of 72% bakuchiol content was confirmed by the experiment under the optimized process conditions.
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KEYWORD
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Chiba seed, bakuchiol, psoralen, molecular distillation, response surface methodology
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